Article information, pdf download for vogtkoyanagiharada syndrome. Make a photocopy of the completed answer form for your own files and mail the. Development and evaluation of diagnostic criteria for vogt. The immune response in vkh syndrome most likely is directed against antigens. Differential diagnosis includes other causes of posteriorpanuveitis, such as sympathetic ophthalmia, uveal effusion syndrome, posterior scleritis. Uveomeningoencephalitic syndrome vogtkoyanagiharanda vkh is an unusual syndrome with important neurological complications and has not. The term vogtkoyanagiharada disease was coined by bruno and mcpherson 8 to encompass the previous reported uveomeningeal syndromes as one widespectrum entity. Melanocytes are specialized cells that produce a pigment called melanin. Vogtkoyanagiharadas disease is a rare syndrome that affects tissues with melanocytes like eyes, central nervous system, skin and inner ear. The vogt koyanagi harada syndrome vkh is a bilateral, diffuse granulomatous uveitis associated with poliosis, vitiligo, alopecia, and central nervous system and auditory signs. Pdf vogtkoyanagiharada syndrome is a bilateral, chronic, diffuse granulomatous panuveitis frequently associated with neurological.
It affects primarily asians, indians and latin americans and also women. Utility of existing vogtkoyanagiharada syndrome diagnostic criteria at initial. Vogtkoyanagiharada disease genetic and rare diseases nih. Vkh syndrome may be defined as a bilateral, chronic, granulomatous panuveitis associated with systemic manifestations that may affect. Pdf a u g u s t 3 1, 2 0 1 0 v o l u m e 9 n u m b e r 1 6 contemporary. Vogtkoyanagiharada disease genetic and rare diseases. Vogtkoyanagiharada syndrome uveomeningoencephalitic.
Vogt koyanagiharada syndrome vkh is a severe bilateral. Vogtkoyanagiharada disease vkh disease is a disease that affects several parts of the body, including the eyes, ears, nervous system, and skin. Vogtkoyanagiharada disease vkhd, initially described as an uveomeningoencephalitic syndrome, is a constellation of clinical symptoms. Uveomeningoencephalitic syndrome vogtkoyanagiharada. Here, we describe a unilateral case of vkh disease. Vogtkoyanagiharada vkh disease is an immunemediated. Vogtkoyanagiharada syndrome vkhs is a rare multisystemic disease which probably has autoimmune etiology. Some ethnic groups have a higher probability of developing the disease, including asians, indians and latin americans and females are affected more often. The signs and symptoms of vkh disease are caused by chronic inflammation of melanocytes.
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